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Home » Cardiac Injection » Acetylcysteine Solution USP
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Acetylcysteine Solution USP

( Our Equivalent Generics )

Acetylcysteine Solution USP 200 mg/ml

Compositions:
Each ml contains Acetylcysteine USP 200 mg

Pharmacological classification & ATC Classification:
V03AB23 - acetylcysteine; Belongs to the class of antidotes. Used to neutralize paracetamol overdose.

Pharmacology:
Acetylcysteine may decrease the viscosity of secretions by splitting of disulphide bonds in mucoproteins. It also promotes the detoxification of an intermediate paracetamol metabolite which is used in the management of paracetamol overdosage.
Absorption: Rapidly absorbed from the GI tract (oral); peak plasma concentrations after 0.5-1 hr.
Distribution: Protein-binding: 50%.
Metabolism: Extensively hepatic.
Excretion: Urine; elimination half-life: 6.25 hr (oral); 5.58 (IV).

Indications:
Acetylcysteine Solution used in Paracetamol poisoning

Dosage & administration:
Intravenous

Paracetamol poisoning
Adult: Initially, 150 mg/kg in 200 ml of infusion fluid given over 15 minutes, followed by 50 mg/kg in 500 ml of infusion given over the next 4 hr, then 100 mg/kg in 1 L of infusion fluid over the next 16 hr. 

Child: Child =20 kg: Initially, 150 mg/kg in 100 ml of infusion fluid given over 15 min, followed by 50 mg/kg in 250 ml of infusion given over the next 4 hr, then 100 mg/kg in 500 mL of infusion fluid over the next 16 hr. Child <20 kg: Doses as per adult dose but adjust volume of based on child age and wt to avoid fluid overload. 

Reconstitution: To be diluted for IV infusion with 5% dextrose, 0.9% sodium chloride, 0.3% potassium chloride with 5% glucose, 0.3% potassium chloride with 0.9% sodium chloride. 

Incompatibility: Incompatible with metals (e.g. iron, copper, nickel), rubber, oxygen, oxidising substances (e.g. hydrogen peroxide), and some (e.g. tetracycline HCl, oxytetracycline HCl, erythromycin lactobionate, ampicillin sodium, amphotericin B). A change in colour of solution to light purple may be observed and does not indicate significant change in safety or efficacy

Incompatibility : Incompatible with metals (e.g. iron, copper, nickel), rubber, oxygen, oxidising substances (e.g. hydrogen peroxide), and some(e.g. tetracycline HCl, oxytetracycline HCl, erythromycin lactobionate, ampicillin sodium, amphotericin B). A change in colour of solution to light purple may be observed and does not indicate significant change in safety or efficacy

Contraindications :
Acetylcysteine is contraindicated in patients with hypersensitivity or previous anaphylactic reaction to acetylcysteine or any component of the preparation.

Precautions:
Asthmatic patients, history of bronchospasm, peptic ulceration. Pregnancy, lactation.

Side Effects:
Flushing, fever, stomatitis, nausea, vomiting, rhinorrhoea, bronchospasm, anaphylactoid reactions, rashes. Rarely, blurred vision, bradycardia, syncope, thrombocytopenia, convulsions.
Potentially Fatal: Rarely, respiratory or cardiac arrest.

Pregnancy & Lactation:
Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Storage:
Intravenous: Store below 25°C

Packing presentations:
(Also can be packed according to customer’s requirement) Vials containing Acetylcysteine USP 200 mg/ml

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