Gentamicin Injection BP 40mg/ml
is the first and only FDA-approved pill proven to treat male pattern
hair loss on the vertex (top of the head) and anterior (mid-scalp
area) in men. Most men reported an increase in the amount of hair, a
decrease in hair loss, and improvement in appearance. The vast
majority of men on were rated as improved by doctors.
Do not use if any particle or suspended matter is visible.
Method of administration :
Special Warnings and Precautions :
- Use in patients hypresensitive to gentamicin.
- Use concurrently with other potentially nephrotoxic or
ototoxic drug substances.
- Gentamicin should be used with caution in premature infacts
because of their renal immatunity, in elderly people and
generally in patients with impaired renal function.
- Diabetes, auditory vestibular dysfunction, otitis media, a
history of otitis media, previous use of ototoxic drugs and
generally determined high sensitivity to aminoglycoside induces
ototoxicity, are other main factors which may pre dispose the
patients the toxicity.
Patients being treated with Gentamicin should be under close
clinical observation because of its potential toxicity.
As with other aminoglycosides toxicity is related to serum
concentration. With 6-8 hourly dosing, serum levels more than 10
micrograms/ml may be associated with effects on the vestibular
mechanism. Toxicity can be minimised by monitoring serum
concentrations and its advisable to check serum levels to confirm
that peak levels (one hour) do not exceed 2 micrograms/ml. Evidence
of toxicity requires adjustment of dosage or withdrawal of the drug.
Concurrent use of other neurotoxic drugs can increase the
possibility of Gentamicin toxicity. Co-administration with the
following agents should be avoided.
Other potentially nephrotoxic or ototoxic drugs such as
cephalosporins and methicilin. Potent diluretics such as ethacrynic
acid and frusemide. Other aminoglycosides
Side effects :
Ototoxicity and nephrotoxicity are the most common side effects
associated with Gentamicin. Both effects are related to renal
impairment and hence the dosage in such patients should be altered
as suggested. Other advsrse reactions associated with gentamicin
therapy include nausea, vomiting, urticaria, reversible
granulocytoperia, allergic contact sensitization and neuromuscular
Drug Interaction :
Pregnanvy & Lactation :
- Antibacterials : Increased risk of nephrotoxicity with
cephalosporins notably cephaloyhin.
- Gentamicin has been known to potentiate anticoagulants such
as warfarin and phenindione.
- Anifungals:Increased risk of nephrotoxicity with
- Cholinerghics:Antagronism of effect of neostigmine and
- Cyclosporin:Increased wisk of nephrotoxicity.
- Cytoxics: Increased risk of nephrotoxicity and possible risk
- Diuretics: Increased risk of ototoxicity with loop
- Muscle relazants: Effect of non-depolarising muscle
relaxants such as tubocurarine enhanced.
Gentamicin should only be used during pregnancy or lactation if
consider essential by the physician. The drug crosses the placenta
and it is excreted in small amounts in breast milk.
As in the case of other aminoglycosides, toxicity is associated
with serum levels above a critical value. In patients with normal
renal function it is unlikly that toxic serum levels(in excess of 10
micrograms/ml) will be reached after administration of recommended
doses. Where higher levels occur because of renal impaiment, dosage
should be reduce. In the evennt of an overdose or toxic reaction,
poritoneal dialysis or haemodialysis will lower serum Gentamicin
Store in a cool day place, Protect from light
Keep out of the reach of children.
410x2 ml Ampoule