for injection BP
Pharmacological Action :
Lekalza Injection is indicated for treatment of the signs and
symptoms of acute and chromoc rheumatoid arthritis, osteoarthritis
and ankylosing spondylities. Painful post-traumaticand
post-operative inflammation and swelling. pain following dental
surgery. Acute attacks of gout. Painful gynaecological conditions.
Dosage and direction for use :
The recommended doses of the diclofenac injection is 1 ampoule (75
mg) once daily or, if required in severe cases twice daily, injected
Diclofenac injectionfor intramuscular and should not be moxed with
other injection solu Lekalza Injection should not be given more than
Lekalza Injection are not recommended for use in children.
As directed by the physician
Lekalza injections is contraindicated in patient who are
hypersensitive to it, and in whom drugs like and other
NSAIDs precipitate attacks of asthma, urticaria or acute rheumatic.
It should be given to patients with pepticuler.
Warning and precautions :
Strict accuracy of diagnosis and close medical surveillance are
imprative in patients with symptoms indicative of a gastrointestinal
disorder with a history suggestive of gastrointestinal ulceration,
with ulcerative colitis or with Crohn's disease and in patients with
severe impairment of hepatic function. It peptic ulceration or
gastrointestinal bleeding occur in patients receiving the drug, it
should be withdrawn.
Caution is necessary in patients with impaired cardiac or renal
function, those being treated with diuretics, and those recovering
from surgical options since prostaglandins play a major role in the
maintenance of the renal blood flow. During the long-term treatment
with Diclofenac Sodium, renal and hepatic function should be
monitored and regular blood count should be taken as precautionary
Side effects :
Perforation of gastriculcers.
GIT haemorrhage, blood dyscriasias and anaphylaxis (rare)
Others: G.I. disturbances, headache, dizziness. rash, pruritus,
G.I.Bleeding: Pepticulcer, abnormalities of liver and kidney
Drug Interaction :
Deterioration in renal function has been attributed to the
concomitant use of Diclofenac and triamterene or cyclosporin. As
with other NSAIDs Diclofenac Sodium is likely to inhibit the
activity of the diuretics. Concomitant treatment with potassium
diuretics may increase the serum potassium levels. Plasma
concentrations of lithium or digoxin are increased when these drugs
are given together with Diclofenac Sodium.
Cholestyramine appears to reduce the biovailability of Diclofenac
Sodium when the two given together.
Concomitant administration of systemic NSAIDs and / or
glucocorticoids may increase the risk of side effects.
Monitoring of patents is required when Diclofenac Sodium is given
along with anticoagulants. As with other NSAIDs Diclofenac Sodium in
high doses may temporarily inhibit platelet aggregation. Blood
levels of menthotrexate may risk and toxicity may increase if
Diclofenac Sodium is administration less than 24 hours before or
after the treatment with methotrexate.
Pregnanvy & Lactation :
Diclofenac Sodium should not be used during the pregnancy and
lactation unless the potential benefits to the mother outweight the
possible risk to fetus since the data available as yet are
There is no typical clinical picture resulting from diclofenac
overdosage. Overdosage can cause symptoms such as vomiting,
gastrointestinal haemorrhage, diarrhoea, dizziness, tinnitus or
convulsions. In the event of significant poisoning, acute renal
failure and liver damage are possible.
Management of acute poisoning with NSAIDs, including diclofenac,
essentially consist of supportive measures and symptomatic
treatment. Supportive measures and symptomatic treatment should be
given for complications such as hypotension, renal failure,
convulsions, gastrointestinal disorder, and respiratory depression.
Special measures such as forced diuresis, dialysis or haemoperfusion
are probably of no help in eliminating NSAIDs, including diclofenac,
due to higher protein binding and extensive metabolism.
Store in a cool day place, Protect from light
Keep out of the reach of children.
3 ml x 10 Ampoule