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Home » Hormone Preparation » Allyloestrenol 5 mg
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Allyloestrenol 5 mg

( Our Equivalent Generics )

Allyloestrenol Tablet 5 mg

Compositions:
Each tablet contains Allyloestrenol 5 mg

Pharmacological classification & ATC Classification:
G03DC01 - allylestrenol ; Belongs to the class of estren derivative progestogens used in progestogenic hormone preparations

Pharmacology:
Allylestrenol is similar to that of natural progesterone. It prepares the uterus for receiving the fertilised ovum and suppresses uterine motility.

Indications:
Allylestrenol is used in circumstances of Threatened miscarriage

Dosage & administration:
Oral
Threatened miscarriage
Adult: 5 mg tid for 5-7 days.

Administration:
May be taken with or without food. (May be taken w/ meals if GI upset occurs.)

Contraindications:
Hypersensitivity; thrombophleobitis; undiagnosed vag bleeding, incomplete abortion, hormone-dependent carcinoma, cerebral apoplexy, as a diagnostic test for pregnancy; severe hepatic impairment; pregnancy

Precautions:
Discontinue medications if there is sudden partial or complete loss of vision, proptosis or diplopia; migraine and embolic disorders; epilepsy, migraine, asthma, cardiac or renal dysfunction. History of depression, glucose tolerance and diabetic patients. My impair ability to drive operate machinery. Sudden withdrawal of allyloestrenol should be avoided as it leads to intermittent breakthrough bleeding; lactation.

Interactions:
Enhanced clearance with enzyme-inducing drugs eg, carbamazepine, griseofulvin, , phenytoin and . may increase bioavailability of progesterone.

Potentially Fatal: Increased ciclosporin concentration.

Side Effects:
GI disturbances, appetite/weight change; fluid retention, oedema; acnes, skin rash, urticaria; depression, headache, fever, fatigue; breast changes, hirsutism, changes in libido, altered menstrual cycles or irregular menstrual bleeding (rare).

Storage:
Store below 25°C

Packing presentations:
(Also can be packed according to customer’s requirement)
Packing of 10, 50, 100, 150 tablets



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Clomifene Citrate 50 mg
( Our Equivalent Generics )
Compositions:
Each tablet contains Clomifene citrate BP 50 mg

Pharmacological classification & ATC Classification:
G03GB02 - clomifene; Belongs to the class of synthetic agents used as ovulation stimulants.

Pharmacology:
Clomifene inhibits the negative feedback mechanisms of oestrogens in the hypothalamus and pituitary which stimulates the secretion of pituitary gonadotrophic hormones resulting in stimulation of ovulation.
Absorption: Absorbed as citrate in the GI tract (oral).
Metabolism: Hepatic; undergoes enterohepatic recycling.
Excretion: Via the urine and bile; via the faeces (as unchanged drug and metabolites). 5-7 days (elimination half-life

Indications:
Treatment of anovulatory infertility and that due to polycystic ovaries.

Dosage & administration:
Oral
Anovulatory infertility
Adult: 50 mg daily for 5 days starting on the 5th day of menstrual cycle or at any time if there is amenorrhoea. If ovulation does not occur, a 2nd course of 100 mg for 5 days may be used commencing as early as 30 days after the previous therapy. Further treatment may not be recommended if pregnancy has not occurred after a total of 6 treatment cycles.

Contraindications:
Hypersensitivity; abnormal bleeding; pregnancy, lactation; liver dysfunction; uncontrolled thyroid or adrenal dysfunction, patient with an organic intracranial lesions such as pituitary tumor.

Precautions:
Polycystic ovaries, evaluate presence of ovarian cyst before each cycle treatment. Uterine fibroids; visual disturbances may develop which will impair ability to drive or operate machinery.

Overdosage:
Nausea, vomiting, vasomotor flushes, blurred vision, spots or flashes, scotomata, ovarian enlargement with pelvic or abdominal pain. GI decontamination in addition to supportive measures.

Interactions: Decreased response with danazol.

Side Effects:
Ovarian enlargement; abdominal pain and bloating; blurred vision; hot flushes; breast discomfort; depression; multiple or ectopic pregnancies; weight gain, nausea, vomiting; endometriosis; headache, convulsions, dizziness, fatigue, vertigo, insomnia; rash.

Pregnancy & Lactation:
Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.

Storage:
Store in a well closed container, protected from light.
Store below 25°C.
Do not remove the blister from the carton until required for use.
KEEP OUT OF REACH OF CHILDREN
Packing presentations:
(Also can be packed according to customer’s requirement)
Pack of 10 tablets

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