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Antimalarial®

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CYGART 80 mg / ml Box of 10 amps


CYGART

80 mg / ml Box of 10 amps NOFOGO
Composition :
Each ml contains:
 
80 mg

Atc Classification & Description:
P01BE02 - ; Belongs to the class of artemisinin and derivative antimalarials. The chemical name of is (3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2benzodioxepine. is a white, crystalline powder that is freely soluble in acetone, soluble in methanol and ethanol, and practically insoluble in water. It has the empirical formula C16H26O5 with a molecular weight of 298.4, and the following structural formula::
Nofogo


Mechanism of Action:
is a potent and rapidly acting blood schizontocide, which is highly efficacious in treating chloroquine-resistant falciparum malaria, and complicated falciparum malaria including cerebral malaria. Its quick onset of effect and high efficacy in bringing down the parasite load are the properties which make this drug a suitable therapeutic option against falciparum infection.
Metabolism: Rapidly hydrolysed to the active metabolite dihydroartemisinin.
Excretion: Elimination half-life: about 4-11 hr after IM or oral admin.

Therapeutic Indications:
For the treatment of all kinds of malaria including the chloroquine-resistant P. falciparum malaria and the first aid of critical malaria.

Dosage and administration:
The drug is used for intramuscular injection, five days course with the initial dose of 3.2mg/kg, followed by 1.6rng/kg for the following 4 days. The initial dose for adults is 160mg (2 ampoules), followed by 80mg (1 ampoule) every time from the 2" to 5th day. The dose for children or overweight patients should be decreased or increased on the basis of the individual weight or under the doctor's prescription.
Administration For Children:
For children, the dose should be chosen as follows:
Adverse Drug Reactions
Mild GI disturbance, dizziness, tinnitus, reduction in reticulocyte and leucocyte counts, nausea, vomiting, abdominal pain, bradycardia, 1st-degree heart block, transient increase in serum transaminases.

Contra-Indication:
is contra-indicated to those patients which have a history of hypersensitivity to .
Precaution :
Pregnancy:
Pregnancy and lactation. Avoid concomitant use of drugs known to prolong QT interval or monitor such patients.
Lactation:
excretes into breast milk. It should not be taken by breast-feeding women.

Drug Interactions :
causes QT prolongation in some patients. Thus concomitant use of erythromycin, , procainamide, quinidine, , amiodarone, bretylium, bepridil, , astemizole, probucol, tricyclic antidepressants, s may be avoided.

Instructions :
  • Each pack contains 10 ampoules of 80 mg/1ml.


Manufacture in India for:
Cygnus Healthcare Specialities Pvt Ltd.
Thane -400607 India

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NOFOGO & Lumefantrine Tablets

NOFOGO

Tablets / Dry Powder for Suspension NOFOGO
Composition :
Each tablet contains:
 
20 mg
Lumefantrine 120 mg
80mg
Lumefantrine 480 mg
40mg
Lumefantrine 240 mg


For suspension:
Each 5 ml contains:
 
15 mg
Lumefantrine 90 mg

Atc Classification & Description:
P01BE02 - ; Belongs to the class of artemisinin and derivative antimalarials. The chemical name of is (3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2benzodioxepine. is a white, crystalline powder that is freely soluble in acetone, soluble in methanol and ethanol, and practically insoluble in water. It has the empirical formula C16H26O5 with a molecular weight of 298.4, and the following structural formula:
Nofogo

The chemical name of lumefantrine is (±)-2-dibutylamino-1-[2,7-dichloro-9-(4-chlorobenzylidene)-9Hfluorene-4-yl]ethanol. Lumefantrine is a yellow, crystalline powder that is freely soluble in N,Ndimethylformamide, chloroform, and ethyl acetate; soluble in dichloromethane; slightly soluble in ethanol and methanol; and insoluble in water. It has the empirical formula C30H32Cl3NO with a molecular weight of 528.9, and the following structural formula:
Nofogo

Mechanism of Action:
is a potent and rapidly acting blood schizontocide, which is highly efficacious in treating chloroquine-resistant falciparum malaria, and complicated falciparum malaria including cerebral malaria. Its quick onset of effect and high efficacy in bringing down the parasite load are the properties which make this drug a suitable therapeutic option against falciparum infection.
Metabolism: Rapidly hydrolysed to the active metabolite dihydroartemisinin.
Excretion: Elimination half-life: about 4-11 hr after IM or oral admin.

Therapeutic Indications:
/ Lumefantrine is indicated for the treatment of uncomplicated P. falciparum malaria including multi-drug resistant strains of P.falciparum. it is also effective against the blood stage of P.vivax but not active against hypnozoites. / Lumefantrine must be used for the malaria infections acquired in areas where the parasites may be resistant to other anti-malarial drugs

Dosage and administration:
Patients with acute malaria are frequently averse to food. The dose may be encouraged to resume normal eating as soon as food can be tolerated since this improves absorption of and Lumefantrine. In the event of vomiting within 1 hour of administration a repeat dose should be taken.
Acute uncomplicated falciparum malaria
Adult: 80 mg daily, to be taken with lumefantrine 480 mg daily. Doses to be taken at diagnosis and repeated after 8, 24, 36, 48 and 60 hr. Total doses: 6.
Child:Daily doses based on body wt: 5-14 kg: 20 mg with lumefantrine 120 mg; 15-24 kg: 40 mg with lumefantrine 240 mg; 25-34 kg: 60 mg with lumefantrine 360 mg and >34 kg: 80 mg with lumefantrine 480 mg. Doses to be taken at diagnosis and repeated after 8, 24, 36, 48 and 60 hr. Total doses: 6.
For 20mg/120mg Tablets:
Child: 5kg to 14kg:   1 B.I.D for 3 day
For 80mg/480mg Tablets:
Adults & over 35kg:   1 B.I.D for 3 days
For 40mg/240mg Tablets:
Adults & over 35kg:   1 B.I.D for 3 days
25kg to 34kg:    1 1/2 B.I.D for 3 days
15kg to 24kg:   1 B.I.D for 3 days

For suspension:
Reconstitution:
After opening the bottle, drinking water is to be added and carefully brought to the mark point indicating 100 ml level. After adding the water, the mixture has to be vigorously shaken until all powder has disappeared from the bottom and a yellow suspension is being formed. The composition of the powder is such that this process will take only a few seconds. It will be necessary to readjust the volume to the 100 ml mark. This suspension is stable for at least 14 days. Although the suspension powder does not precipitate to the bottom, it is advisable to shake the bottle before use so there is a homogeneous distribution of the active ingredients. A subunit of 5 ml of the 100 ml made suspension contains 15 mg and 90 mg lumefantrine.
Dosage:
Once Daily for Three Day
Body Weight (Kg) 5 - 7.4 7.5 - 9.9 10 - 12.4 12.5 - 14.9 15 - 17.4 17.5 - 19.9
Dosage 7 ml 10 ml 14 ml 17 ml 20 ml 24 ml

Adverse Drug Reactions:
Mild GI disturbance, dizziness, tinnitus, reduction in reticulocyte and leucocyte counts, nausea, vomiting, abdominal pain, bradycardia, 1st-degree heart block, transient increase in serum transaminases.

Contra-Indication:
/ Lumefantrine is contra-indicated to those patients which have a history of hypersensitivity to / Lumefantrine.
Precaution :
Pregnancy:
Pregnancy and lactation. Avoid concomitant use of drugs known to prolong QT interval or monitor such patients.
Lactation: / Lumefantrine excretes into breast milk. It should not be taken by breast-feeding women.

Drug Interactions :
causes QT prolongation in some patients. Thus concomitant use of erythromycin, , procainamide, quinidine, , amiodarone, bretylium, bepridil, , astemizole, probucol, tricyclic antidepressants, s may be avoided.

Instructions :
  • Keep out of reach of children.
  • Avoid exposure to heat, light and humidity.
  • Store in a cool place (below 25°C).
  • Improper storage may deteriorate the medicine.

Presentation:
Tablets: pack of 6's tablets
Powder for Suspension: 100 ml bottle

Manufacture in India for:
Brunhild Pharmaceuticals Pvt Ltd.
Naigaon-401102 INDIA.

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NOFOGO-S & Lumefantrine Powder For Oral Suspension 100ml bottle

NOFOGO-S
This syrup is highly effective in curing deceased for which it is prescribed by the doctors.
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