Cygnus Healthcare Specialities Private Limited

Description:

• Paracetamol solution for infusion is a clear and slightly yellowish solution. It contains 10mg/mL of paracetamol. Paracetamol is a white crystalline solid or powder chemically described as 4 - acetaminophen.

Clinical Pharmacology:

• Pharmacodynamics
• Paracetamol 10 mg/mL, solution for infusion provides onset of pain relief within 5 to 10 minutes after the start of administration. The peak analgesic effect is obtained in 1 hour and the duration of this effect is usually 4 to 6 hours. Paracetamol 10 mg/mL, solution for infusion reduces fever within 30 minutes after the start of administration with a duration of the antipyretic effect of at least 6 hours.

Pharmacokinetics:

• Adults
• Absorption: Paracetamol pharmacokinetics are linear after a single administration of up to 2 g and after repeated administration during 24 hours.

Distribution:

• The volume of distribution of paracetamol is approximately 1 L/kg.
• Paracetamol is not extensively bound to plasma proteins.
• Following infusion of 2g proparacetamol, (equivalent to 1g of paracetamol) significant concentrations of paracetamol (about 1.5 µg/mL) were observed in the cerebrospinal fluid 20 minutes after infusion.

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Atc Classification & Description:

• P01BE02 - ; Belongs to the class of artemisinin and derivative antimalarials. The chemical name of is (3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2benzodioxepine. is a white, crystalline powder that is freely soluble in acetone, soluble in methanol and ethanol, and practically insoluble in water. It has the empirical formula C16H26O5 with a molecular weight of 298.4.

Mechanism of Action:

• is a potent and rapidly acting blood schizontocide, which is highly efficacious in treating chloroquine-resistant falciparum malaria, and complicated falciparum malaria including cerebral malaria. Its quick onset of effect and high efficacy in bringing down the parasite load are the properties which make this drug a suitable therapeutic option against falciparum infection.
• Metabolism: Rapidly hydrolysed to the active metabolite dihydroartemisinin.
• Excretion: Elimination half-life: about 4-11 hr after IM or oral admin.

Therapeutic Indications:

• For the treatment of all kinds of malaria including the chloroquine-resistant P. falciparum malaria and the first aid of critical malaria.

Dosage and administration:

• The drug is used for intramuscular injection, five days course with the initial dose of 3.2mg/kg, followed by 1.6rng/kg for the following 4 days. The initial dose for adults is 160mg (2 ampoules), followed by 80mg (1 ampoule) every time from the 2" to 5th day. The dose for children or overweight patients should be decreased or increased on the basis of the individual weight or under the doctor's prescription.
• Administration For Children:
• For children, the dose should be chosen as follows:

Administration For Children:

• For children, the dose should be chosen as follows:
• Adverse Drug Reactions
• Mild GI disturbance, dizziness, tinnitus, reduction in reticulocyte and leucocyte counts, nausea, vomiting, abdominal pain, bradycardia, 1st-degree heart block, transient increase in serum transaminases.

Contra-Indication:

• is contra-indicated to those patients which have a history of hypersensitivity to .
• Precaution :
• Pregnancy:
• Pregnancy and lactation. Avoid concomitant use of drugs known to prolong QT interval or monitor such patients.
• Lactation:
• excretes into breast milk. It should not be taken by breast-feeding women.

Drug Interactions :

• causes QT prolongation in some patients. Thus concomitant use of erythromycin, , procainamide, quinidine, , amiodarone, bretylium, bepridil,, probucol, tricyclic antidepressants, s may be avoided.

Instructions :

• Each pack contains 10 ampoules of 80 mg/1ml.

Other Details:-

• Each 1 Ml Contains 
• Artemether Ip ...80 Mg
• Antimalarial
• 6 Ampoules +12 Alcoholic Swabs

Metronidazole Injection is used to treat Anaerobic bacterial infections, infections by Bacteroides fragilis. It is also used to tackle some infections by Fungi Bacteria, Eubacteria Clostridia, Anaerobic cocci, Gingivitis pericoronitis. It is also administered on patients before, during and after surgery.

Rare side effects include discomfort, nausea, gastro-intestinal disturbances.

Patients with treatment more than 10 days must be strictly monitored.

Check with your general physician regarding any allergies and pre existing conditions and administer Metronidazole Injection as per prescription.